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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often focused on the practical aspects of the study design, such as the recruitment process and consent in adherence, as well as the use of routinely available equipment.
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A practical trial that employs a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be valid and also reduces bias in the results. However, too much heterogeneity can result in problems with the design of the trial.
Pragmatic Play Pragmatic Play, a major player on the live casino market offers various classic table games like Blackjack and Roulette. The company’s live studios in Romania and Malta offer a real-life gambling experience for customers, as well as a wide range of virtual betting options. The company also has created several interactive game shows to make gambling online enjoyable. Some of these shows have a live host, while others are hosted by prominent personalities from the industry.
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The goal of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. They are usually commissioned by policymakers and practitioners in order to guide their decisions. They also provide a useful method to determine the cause-effect relationship between an intervention and its results. However, they should not be used to substitute for explanation studies.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which confirm the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a pragmatic study, including the recruitment process, the design and 프라그마틱 환수율 delivery of the intervention, as well as follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note, however, that the majority of these studies were conducted in primary care settings.