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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically characterized by a focus on the practical aspects of study design, such as the recruitment process and consent in adherence, as well as the use of commonly available equipment.
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A pragmatic trial that uses a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be valid and 프라그마틱 정품 사이트 also helps to reduce the chance of bias in the results. However, too much heterogeneity, can cause problems with the trial design.
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The goal of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. Usually, they are requested by practitioners and policymakers to inform their decisions. They can also be used to determine the cause-effect relationship of an intervention and 프라그마틱 불법 its results. They should, however, not, be used to replace explanation studies.
The pragmatism idea is controversial, and 프라그마틱 무료스핀 there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which confirm the physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a practical trial which includes the recruitment process, the design and delivery of the intervention, as well as monitoring.
The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) resulted in 34 articles, as shown in red in Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to note that the majority were conducted in primary-care settings.