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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described by their focus on practical aspects of designing a study, including the recruitment process and consent, adhering and the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and had participants from various geographical areas. This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity and also helps reduce the chance of bias in the results. However excessive heterogeneity could cause issues with the design of the trial.
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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually commissioned by policy makers and 프라그마틱 슬롯무료 practitioners to guide their decision-making. They are also a good method of determining the causality between an intervention and its results. However, they shouldn’t be used to substitute for explanation trials.
The concept of pragmatism is controversial and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, 프라그마틱 무료 슬롯 which validate the clinical or physiological hypothesis, and pragmatic trials, which guide the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the elements of a practical study, including recruitment, design, implementation of the intervention and follow-up.
There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of these trials were conducted in primary care settings.